Controlled sustained release tablets containing bupropion

A controlled sustained release tablet comprising an admixture of 25 to 500 mg of bupropion hydrochloride particles, hydroxypropyl methycellulose and glycine hydrochloride or cysteine hydrochloride and having a surface to volume ratio of 3:1 to 25:1 cm.sup.-1.

A controlled sustained release tablet comprising an admixture of 50 to 150 mg of bupropion hydrochloride particles, hydroxypropyl methylcellulose, and cysteine hydrochloride and having a surface to volume ratio of 7:1 to 16:1 cm.sup.-1.

A controlled sustained release tablet comprising an admixture of 50 to 500 mg of bupropion hydrochloride particles, hydroxypropyl methylcellulose and glycine hydrochloride and having a surface to volume ratio of 7:1 to 16:1 cm.sup.1.

A controlled sustained release tablet comprising an admixture of 50 mg of bupropion hydrochloride and hydroxyprophyl methylcellulose which after oral administration of a single one of said tablets in adult men produces plasma levels of bupropion as free base ranging between the minimum and maximum levels as shown in FIG. 4 over twenty four hours.

A controlled sustained release tablet comprising an admixture of 100 mg of bupropion hydrochloride and hydroxypropyl methylcellulose which after oral administration of a single one of said tablets in adult men produces plasma levels of bupropion as free base ranging between the minimum and maximum levels as shown in FIG. 5 over twenty four hours.

A controlled sustained release tablet comprising an admixture of 150 mg of bupropion hydrochloride and hydroxypropyl methylcellulose which after oral administration of a single one of said tablets in adult men produces plasma levels of bupropion as free base ranging between the minimum and maximum levels as shown in FIG. 6 over twenty four hours.

A sustained release tablet containing a mixture of (a) 50 mg of bupropion hydrochloride and (b) means for releasing between about 30 and 50 percent of bupropion hydrochloride in one hour, between about 70 and 95 percent in four hours and not less than 80 percent in 8 hours in distilled water said means comprising hydroxypropyl methylcellulose.

A sustained release tablet containing a mixture of (a) 100 mg of bupropion hydrochloride and (b) means for releasing between about 25 and 45% of bupropion hydrochloride in one hour, between 60 and 85% in 4 hours and not less then 80% in eight hours in distilled water said means comprising hydroxypropyl methylcellulose.

A sustained release tablet containing a mixture of (a) 150 mg of bupropion hydrochloride and (b) means for releasing about between 25 and 45% of bupropion hydrochloride in one hour, between about 60 and 85% in four hours and not less than 80% in eight hours in distilled water said means comprising hydroxypropyl methylcellulose.