Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy
AssigneeInstitut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
InventorsMayk Kresse, Rudiger Lawaczeck, Detlef Pfefferer
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Abstract
The invention relates to nanocrystalline magnetic particles consisting of gnetic iron oxide core of Fe.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and an envelope chemisorbed to said core, the method for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy. The magnetic particles, according to the invention, are characterized by composition of the coating material of natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives.
Claims11
Nanocrystalline magnetic particles consisting of a magnetic iron oxide core of FE.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and a chemisorbed coating on this core, wherein composition of the coating material of natural or synthetic glycosaminoglycans and/or derivatives thereof with molecular weights of 500 Da to 250,000 Da combined, optionally covalently cross-linked by appropriate cross-linking agents and/or modified by specific additives.
Diagnostic and/or therapeutic agents comprising optionally isotope doped iron oxide cores of FE.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or their mixtures, which are surrounded by a biodegradable coating of natural or synthetic glycosaminoglycans and/or derivatives thereof with molecular weights between 500-250,000 Da, with the coating molecules possibly being cross-linked by cross-linking agents and modified by surface-active substances, targetable structure substances and lower molecular weight residues.
Dependencies are inferred from the claim text.