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US 5,426,224 AGranted
Mammalian DNA topoisomerase II inhibitor and method
AssigneeThe University of North Carolina at Chapel Hill
InventorsKuo-Hsiung Lee, Kenneth F. Bastow
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Abstract
A novel antiproliferative drug and methods are disclosed. The drug has the general structural formula: ##STR1## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is an acylamino, or aroylamino group. The compound is useful for inhibiting cell proliferation in drug-resistant tumor cells. Also disclosed is a method of chemical converting a colchicine derivative to form an active inhibitor of DNA topisomerase II.
Claims2
A compound having the structure:
- ##STR3## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is a 3,4,5-trihydroxybenzoy)amino group.
Dependencies are inferred from the claim text.