Bioabsorbable melt spun fiber based on glycolide-containing copolymer
AssigneeUnited States Surgical Corporation
InventorsJohn Kennedy, Cheng-Kung Liu
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Abstract
A bioabsorbable fiber useful for the manufacture of medical devices is obtained from a polymer containing from about 15 to about 30 mole percent glycolide in a melt spinning operation carried out under low shear conditions. The fiber is drawn at a ratio of about 1.5 to 2.7. The fiber possesses excellent tensile strength and a high level of retention of its original strength on storage.
Claims23
A bioabsorbable filament drawn at a ratio of about 1.5 to 2.7, in which glycolide content is in the range of from about 15 to about 30 mole percent, said filament having a tensile strength of at least about 70,000 psi at zero time.
A bioabsorbable fiber obtained from a process which comprises
- melt spinning a polymer in which glycolide content is in the range of from about 15 to about 30 mole percent and inherent viscosity as measured in chloroform at about 30.degree. C. in a concentration of about 0.25 g/dl is at least about 1.0 dl/g at a shear rate not exceeding about 1,000 sec.sup.-1, and
- drawing the thus spun fiber at a ratio of about 1.5 to 2.7, to provide a bioabsorbable melt spun fiber possessing a tensile strength of at least about 70,000 psi at zero time.
A bioabsorbable fiber obtained from a process which comprises
- melt spinning a polymer in which glycolide content is in the range of from about 15 to about 30 mole percent at a shear rate not exceeding about 1,000 sec.sup.-1, and
- drawing the thus spun fiber at a ratio of about 1.5 to 2.7,
- to provide a bioabsorbable melt spun fiber possessing a tensile strength of at least about 70,000 psi at zero time and an inherent viscosity, as measured in chloroform at about 30.degree. C. in a concentration of about 0.25 g/dl, of at least about 1.0 dl/g.
A bioabsorbable fiber obtained from a process which comprises
- melt spinning a polymer in which glycolide content is in the range of from about 15 to about 30 mole percent and inherent viscosity as measured in chloroform at about 30.degree. C. in a concentration of about 0.25 g/dl is at least about 1.0 dl/g at a shear rate not exceeding about 1,000 sec.sup.-1, and
- drawing the thus spun fiber at a ratio of about 1.5 to 2.7,
- to provide a bioabsorbable melt spun fiber possessing a tensile strength of at least 70,000 psi at zero time, and retaining at least about 80% of its tensile strength after about a four week period in vitro at about 37.degree. C.
A bioabsorbable drawn fiber obtained from a process which comprises
- melt spinning a polymer in which glycolide content is in the range of from about 15 to about 30 mole percent at a shear rate not exceeding about 1,000 sec.sup.-1 to provide a bioabsorbable melt spun fiber and then drawing said melt spun fiber at a ratio of about 1.5 to 2.7,
- to provide a drawn fiber possessing a tensile strength of at least about 70,000 psi at zero time and an inherent viscosity, as measured in chloroform at about 30.degree. C. in a concentration of about 0.25 g/dl, of at least about 1.0 dl/g.
A bioabsorbable surgical article manufactured from a plurality of fibers, at least one of said fibers being produced by a process which comprises
- melt spinning, at a shear rate not exceeding about 1,000 sec.sup.-1, a polymer containing from about 15 to about 30 mole percent glycolide, and
- drawing the melt spun fiber at a ratio of about 1.5 to 2.7 to orient the polymer and increase tensile strength thereof,
- whereby a bioabsorbable melt spun fiber possessing a tensile strength of at least about 70,000 psi at zero time is prepared.
The article 19 wherein the fiber is drawn at a ratio of about 1.6 to 2.5.
Dependencies are inferred from the claim text.