Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
OwnerJohn Enginventor
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Abstract
This invention encompasses pharmaceutical compositions containing exendin-3 or exendin-4, fragments thereof, or any combination thereof, and methods for the treatment of diabetes mellitus and the prevention of hyperglycemia.
Claims7
A polypeptide having the amino acid sequence:
- HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG P[SEQ ID No:3].
A polypeptide having the amino acid sequence:
- HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG Y[SEQ ID No:4].
A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:
- HSDGTFITSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO:
- 1),
- wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1.
A method of stimulating insulin release in a mammal comprising administering an effective insulinotropic amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:
- HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO:
- 2),
- wherein the resulting insulinotropic effect is greater than that attainable by administration of GLP-1.
A method of inhibiting insulin release in a mammal comprising administering an effective amount of a substantially pure polypeptide, synthetic or purified from natural sources, having the amino acid sequence:
- DL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS (SEQ ID NO:
- 5).
Dependencies are inferred from the claim text.