Phorbol ester pharmaceutical compositions and their use for treating inflammation
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsPeter M. Blumberg, Zoltan Szallasi
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Abstract
The present invention relates to a method of inhibiting the protein kinase C-mediated biological response inflammation. The method comprises administering to a mammal a non-tumor promoting 12-deoxyphorbol ester. Phorbol esters suitable for use in the method include 12-deoxyphorbol 13-monoesters wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanote, benzoate or phenylacetate ester. The invention also relates to novel 12-deoxyphorbol 13-monoesters, wherein the ester can be a formate, propionate, butyrate or pentanoate ester, and to pharmaceutical compositions comprising same.
Claims13
A pharmaceutical composition comprising a 12-deoxyphorbol 13-monoester, wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanoate, benzoate, or phenyl acetate ester, in an amount sufficient to treat inflammation, together with a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a 12-deoxyphorbol 13-monoester, wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanoate, benzoate, or phenyl acetate ester, in an amount sufficient to treat inflammation, together with a pharmaceutically acceptable carrier, wherein said carrier is not a volatile organic solvent.
A pharmaceutical composition comprising a 12-deoxyphorbol 13-monoester, wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanoate, benzoate, or phenyl acetate ester, in an amount sufficient to treat inflammation, together with a pharmaceutically acceptable carrier, wherein said composition is in dosage unit form.
A pharmaceutical composition comprising a 12-deoxyphorbol 13-monoester, wherein the ester is a formate, acetate, propionate, butyrate, pentanoate, hexanoate, benzoate, or phenyl acetate ester, in an amount sufficient to treat inflammation, together with a pharmaceutically acceptable carrier, wherein said composition is in the form of a lotion, gel, ointment, or cream.
A method of treating inflammation in a mammal in need thereof comprising administering to said mammal a 12-deoxyphorbol 13-monoester that is effective in the treatment of inflammation in an effective amount to treat said inflammation.
Dependencies are inferred from the claim text.