Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsRobert H. Reid, Edgar C. Boedeker, John E. van Hamont, Jean A. Setterstrom
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Abstract
This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres.
Claims14
An immunostimulating composition comprising encapsulation-microspheres, which may contain a pharmaceutically-acceptable adjuvant, wherein said microspheres having a diameter between 1 nanometers (nm) to 10 microns (um) are comprised of (a) a biodegradable-biocompatible poly (DL-lactide-co-glycolide) or polyglycolide as the bulk matrix, wherein the relative ratio between the amount of lactide;
- glycolide components are within the range of 52:48 to 0:100 and (b) an immunogenic substance comprising Colonization Factor Antigen and hepatitis B surface antigen that serves to elicit the production of antibodies and T-lymphocyte proliferation in animals.
An immunostimulating composition comprising encapsulating-microspheres, which may contain a pharmaceutically-acceptable adjuvant, wherein said microspheres having a diameter between 1 nanometers (nm) to 10 microns (um) are comprised of (a) a glycolide polymer as a bulk matrix and (b) an immunogenic substance comprising Colonization Factor Antigen and hepatitis B surface antigen that serves to elicit the production of antibodies and T-lymphocyte proliferation in animals.
Dependencies are inferred from the claim text.