Thermoplastic polymer composition and medical devices made of the same
AssigneeTerumo Kabushiki Kaisha
InventorsFumiaki Endo, Nobuko Saiga
Life of this patent
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Abstract
A thermoplastic polymer composition containing a protease inhibiting substance and medical devices entirely or partly made of the thermoplastic polymer composition. Various medical devices having a good compatibility with blood can be made easily by melt-molding the thermoplastic polymer composition. The anti-thrombotic property of the medical devices lasts for a longer time because the protease inhibiting substance exudes out to the surface if rubbed off.
Claims24
A thermoplastic polymer composition comprising a mixture of thermoplastic polymer and a protease inhibiting substance having a decomposition temperature higher than a melting point of the thermoplastic polymer and at least an amidino group, positively ionized amidino group, guanidino group, or positively ionized guanidino group.
A medical device entirely or partly made of a thermoplastic polymer composition, said thermoplastic polymer composition comprising a mixture of thermoplastic polymer and a protease inhibiting substance having a decomposition temperature higher than a melting point of the thermoplastic polymer and at least an amidino group, positively ionized amidino group, guanidino group, or positively ionized guanidino group.
A method for preparing a thermoplastic polymer composition for making a medical device comprising melt-kneading a thermoplastic polymer composition and a protease inhibiting substance having a decomposition temperature higher than a melting point of the thermoplastic polymer.
A method for making a medical device comprising mixing a thermoplastic polymer composition with a protease inhibiting substance having a decomposition temperature higher than a melting point of the thermoplastic polymer by melt-kneading to form a mixed composition, and forming said mixed composition into a shape of a medical device.
Dependencies are inferred from the claim text.