Back to results
US 5,416,203 AGranted
Steroid modified oligonucleotides
AssigneeNorthwestern University
InventorRobert L. Letsinger
Life of this patent
Estimating the term…
Abstract
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: ##STR1## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; B is a naturally occurring base, the steroid is bound to the oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.
Claims6
An oligonucleotide and a steroid conjugated to said oligonucleotide, said oligonucleotide comprising:
- ##STR16## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms;
- B is a naturally occurring base, the steroid is bound to said oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.
Dependencies are inferred from the claim text.