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US 5,415,994 AGranted
Lateral flow medical diagnostic assay device with sample extraction means
AssigneeQuidel Corporation
InventorsMichael R. Imrich, John K. Zeis, Steven P. Miller, Allan D. Pronovost
Life of this patent
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Abstract
The present invention provides devices, methods, and kits for treatment and detection of analytes requiring pretreatment in samples. One-step treatment and detection is possible utilizing the devices and methods of the present invention.
Claims21
A device for detecting the presence of an analyte in a sample contained on a swab, said device comprising:
- an extraction chamber for extracting the analyte from the sample wherein the extraction chamber is disposed over a sample receiving zone on a matrix, and wherein the extraction chamber includes a bowl portion for receiving a liquid extraction solution and a cylindrical portion for receiving the swab;
- and
- a matrix having a sample receiving zone for receiving the extraction liquid containing the analyte, a labelling zone having means for specifically labelling the analyte as it passes therethrough and a capture zone having means for specifically binding the labelled analyte thereon, wherein the sample receiving zone, the labelling zone and the capture zone are arranged on the matrix in a liquid flow path.
A device for simultaneously detecting the presence of a plurality of analytes in a sample contained on a swab, said device comprising:
- an extraction chamber for extracting the analyte from the sample wherein the extraction chamber is disposed over a sample receiving zone on a matrix, and wherein the extraction chamber includes a bowl portion for receiving a liquid extraction solution and a cylindrical portion for receiving the swab;
- and
- a matrix having a sample receiving zone for receiving the extraction liquid containing the analyte, a labelling zone having means for specifically labelling each of the analytes as they pass therethrough and at least one capture zone having means for specifically binding a first labelled analyte thereon and at least one capture zone for specifically binding a second labelled analyte, wherein the sample receiving zone, the labelling zone and the capture zones are arranged on the matrix in a liquid flow path.
Dependencies are inferred from the claim text.