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US 5,414,017 AGranted
Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
AssigneeE. R. Squibb & Sons, Inc.
InventorsNorma G. Delaney, George C. Rovnyak, Melanie J. Loots
Life of this patent
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Abstract
Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.
Claims7
A compound of the formula ##STR54## wherein X is ##STR55## m is zero or 1;
- n is zero, 1 or 2;
- p is zero or 1 to 6 provided that m and p are not both zero;
- R.sub.1 is hydrogen, lower alkyl, halo substituted lower alkyl, ##STR56## --(CH.sub.2).sub.r --COR.sub.9, --(CH.sub.2).sub.r --cycloalkyl, --(CH.sub.2).sub.r --(.alpha.-naphthyl), --(CH.sub.2).sub.r --(.beta.-naphthyl), ##STR57## --(CH.sub.2).sub.r --NH.sub.2, --(CH.sub.2).sub.r --SH, --(CH.sub.2).sub.r --S-lower alkyl, --(CH.sub.2).sub.r --OH, ##STR58## --(CH.sub.2).sub.r --O-lower alkyl, ##STR59## R.sub.2 and R.sub.9 are independently hydroxy, lower alkoxy, (phenyl) lower alkoxy, ##STR60## --O.sup.- M.sup.+ where M.sup.+ is a salt forming metal ion, ##STR61## or --NRR';
- R and R' are independently hydrogen, alkyl or ##STR62## R.sub.3 is hydrogen or ##STR63## R.sub.4 is hydrogen, lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, halo, hydroxy, CF.sub.3, phenyl, ##STR64## R.sub.5 is lower alkyl, ##STR65## --(CH.sub.2).sub.q --(.alpha.-naphthyl), --(CH.sub.2).sub.q --(.beta.-naphthyl), or --(CH.sub.2).sub.q -cycloalkyl;
- R.sub.6 is hydrogen, lower alkyl, cycloalkyl or phenyl;
- R.sub.7 is hydrogen, lower alkyl, lower alkoxy or phenyl;
- r is an integer from 1 to 4;
- and
- q is zero or an integer from 1 to 7.
6 more elements
Dependencies are inferred from the claim text.