HIV protease inhibitors useful for the treatment of AIDS

A compound of the formula ##STR295## wherein V is absent or ##STR296## wherein Q is absent or --O--, --NR--, or heterocycle optionally sustituted with --C.sub.1-4 alkyl;

• R.sup.1 is:
• 1) --C.sub.1-4 alkyl unsubstituted or substituted with one or more of
• a) halo,
• b) C.sub.1-3 alkoxy,
• c) aryl unsubstituted or substituted with one or more of C.sub.1-4 alkyl, amino, hydroxy or aryl,
• d) --W--aryl or --W--benzyl, wherein W is --O--, --S--, or --NH--,
• e) a 5-7 membered cycloalkyl group unsubstituted or substituted with one or more of
• i) halo,
• ii) C.sub.1-3 alkoxy, or
• iii) aryl,
• f) heterocycle unsubstituted or substituted with one or more of oxo, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkyl;
• ##STR297## or Boc, ##STR298## i) --NH--SO.sub.2 C.sub.1-3 alkyl, j) --NR.sub.2, and R is hydrogen or C.sub.1-4 alkyl;
• k) --COOR, or
• l) --((CH.sub.2).sub.m O).sub.n R wherein in is 2, 3, 4, or 5, and n is zero, 1,2 or 3, or
• 2) aryl, unsubstituted or substituted with one or more of
• a) halo,
• b) hydroxy,
• c) --NO.sub.2 or --NR.sub.2,
• d) C.sub.1-4 alkyl,
• e) C.sub.1-3 alkoxy, unsubstituted or substituted with one or more of C.sub.1-3 alkoxy, ##STR299## q) --R.sup.5, as defined below;
• or 4) heterocycle unsubstituted or substituted with one or more of oxo, halo, amino, C.sub.1-4 alkoxy, C.sub.1-4 alkyl;
• or Boc;
• 5) carbocyclic unsubstituted or substituted with one or more of halo, amino, or C.sub.1-4 alkoxy;
• R.sup.3 is benzyl, unsubstituted or substituted with one or more of (1) hydroxy, (2) C.sub.1-3 alkoxy substituted with one or more of --OH or (3) ##STR300## R.sup.5 is 1) --1) --W--(CH.sub.2).sub.m --NR.sup.6 R.sup.7 wherein W is as defined above, m is 2,3,4 or 5, and R.sup.6 and R.sup.7 are independently
• a) hydrogen,
• b) C.sub.1-6 alkyl, unsubstituted or substituted with one or more of
• i) C.sub.1-3 alkoxy, or
• ii) --NR.sub.2,
• c) the smile or different and joined together to form a 5-7 member heterocycle, such as morpholino, containing up to two additional heteroatoms selected from ##STR301## the heterocycle optionally substituted with C.sub.1-4 alkyl, or d) aromatic heterocycle unsubstituted or substituted with one or more of
• i) C.sub.1-4 alkyl, or
• ii) --NR.sub.2,
• 2) --(CH.sub.2)q--NR.sup.6 R.sup.7 wherein q is 1,2,3,4, or 5, and R.sup.6 and R.sup.7 are defined above, except that R.sup.6 or R 7 are not H or unsubstituted C.sub.1-6 alkyl, or
• 3) benzofuryl, indolyl, azacycloalkyl, azabicyclo C.sub.7-11 cycloalkyl, or benzopiperidinyl, unsubstituted or substituted with C.sub.1-4 alkyl;
• R.sup.12 is ##STR302## or pharmaceutically acceptable salt thereof.