Process for producing optically active 1,3-butanediol by reduction of 4-hydroxy-2-butanone
AssigneeDaicel Chemical Industries, Ltd.
InventorsAkinobu Matsuyama, Teruyuki Nikaido, Yoshinori Kobayashi
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Abstract
An optically active 1,3-butanediol can be produced by either (1) treating a mixture of 1,3-butanediol enantiomers with a microorganism, which has been optionally treated, capable of asymmetrically assimilating said mixture, or (2) preparing a microorganism, which has been optionally treated, capable of asymmetrically reducing 4-hydroxy-2-butanone, and collecting optically active 1,3-butanediol.
Claims13
A process for producing optically active 1,3 butandiol, which comprises treating 4-hydroxy-2-butanone with a microorganism, capable of asymmetrically reducing 4-hydroxy-2-butanone into either (R)-1,3-butanediol or (S)-1,3-butanediol, said microorganism being selected from the group consisting of:
- Ambrosiozyma cicatricosa
- Bacillus cereus
- Bacillus subtilis
- Candida cariosilignicola
- Candida arborea
- Candida kefyr (Beijerinck)
- Candida krusei (Castellani)
- Candida succiphila
- Candida utilis
- Citrobacter freundii
- Corynebacterium michiganense
- Hansenula polymorpha
- Hansenula minuta
- Hansenula subpelliculosa
- Hansenula fabianii
- Hansenula wickerhamii
- Hansenula wingei
- Issatchenkia scutulata var. scutulata
- Issatchenkia scutulata
- Kluyveromyces drosophilarum
- Kluyveromyces lactis
- Pichia cellobiosa
- Pichia heedii
- Pichia lindneri
- Pichia opuntiae var. thermotolerans
- Pichia pastoris
- Pichia trehalophia
- Protaminobacter ruber
- Pseudomonas diminuta
- Pseudomonas fluorescens
- Pseudomonas putida
- Stephanoascus ciferrii
- Rhodotorula rubra
- Selenotila peltata
- Schizosaccharomyces pombe
- Xanthomonas maltophilia
- Brevibacterium iodinum
- Candida rugosa
- Candida parapsilosis
- Geotrichum candidum
- Geotrichum rectangulatum
- Geotrichum klebahnii
- Geotrichum fermentans
- Geotrichum capitatum
- Geotrichum eriense
- Klebsiella pneumoniae
- Lodderomyces elongisporus
- Saccharomycopsis lipolytica
- Trichosporon cutaneum and
- Trichosporon capitatum
- and (2) collecting the (R)-1,3-butanediol or (S)-1,3-butanediol thus formed.
A process for producing optically active 1,3 butandiol, which comprises treating 4-hydroxy-2-butanone with a microorganism, capable of asymmetrically reducing 4-hydroxy-2-butanone into either (R)-1,3-butanediol or (S)-1,3-butanediol, said microorganism being selected from the group consisting of:
- ______________________________________ Ambrosiozyma cicatricosa IFO 1846 Bacillus cereus AHU 1355 Bacillus subtilis IFO 3007 Candida kefyr (Beijerinck) DSM 70073 Candida krusei (Castellani) DSM 70075 Citrobacter freundii AHU 1534 Corynebacterium michiganense IFO 13762 Hansenula polymorpha ATCC 26012 Hansenula minuta DSM 70274 Hansenula subpelliculosa IFO 0808 Hansenula fabianii IFO 1254 Hansenula wickerhamii DSM 70280 Hansenula wingei DSM 70281 Issatchenkia scutulata var. IFO 10070 scutulata Issatchenkia scutulata IFO 10069 Kluyveromyces drosophilarum IFO 1012 Pichia cellobiosa DSM 2147 Pichia heedii IFO 10019 Pichia heedii IFO 10020 Pichia pastoris DSM 70382 Pichia trehalophia DSM 70391 Protaminobacter ruber IAM 1081 Pseudomanas diminuta IFO 12697 Pseudomanas fluorescens IFO 3081 Pseudomonas putida IFO 3738 Stephanoascus ciferrii IFO 1854 Rhodotorula rubra IFO 0383 Selenotila peltata DSM 70579 Schizosaccharomyces pombe IFO 0363 Xanthomonas maltophilia IFO 12690 Brevibacterium iodinum IFO 3558 Candida rugosa IFO 1364 Candida parapsilosis IFO 0640 Candida parapsilosis IFO 0708 Geotrichum candidum IFO 4601 Geotrichum candidum IFO 5767 Geotrichum rectangulatum JCM 1750 Geotrichum klebahnii JCM 2171 Geotrichum fermentans JCM 2467 Geotrichum capitatum JCM 3908 Geotrichum eriense JCM 3912 Klebsiella pneumoniae IFO 12009 Lodderomyces elongisporus IFO 1676 Saccharomycopsis lipolytica IFO 1550 Trichosporon cutaneum IFO 1198 and Trichosporon capitatum IFO 0743 ______________________________________
- and (2) collecting the (R)-1,3-butanediol or (S)-1,3-butanediol thus formed.
A process for producing optically active 1,3-butanediol, which comprises:
- (a) centrifuging, washing and resuspending in a buffer solution cells of microorganisms selected from the group consisting of:
- ______________________________________ Candida utilis IFO 0639 Candida parapsilosis IFO 1396 Geotrichum candidum IFO 5368 Kluyveromyces lactis IFO 1267 and Pichia opuntiae var. IFO 10025 thermotolerans ______________________________________
- (b) treating 4-hydroxy-2-butanone with this solution;
- and
- (c) recovering either (R)-1,3-butanediol or (S)-1,3-butanediol.
Dependencies are inferred from the claim text.