Osmotic dosage system for liquid drug delivery
AssigneeAlza Corporation
InventorsPatrick S. L. Wong, Felix Theeuwes, Brian L. Barclay, Michael H. Dealey
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Abstract
An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
Claims2
An osmotic system for delivering a therapeutic drug formulation to an environment of use, wherein the osmotic system comprises:
- (a) a capsule comprising an internal lumen;
- said capsule formed of gelatin having a viscosity of 15 to 20 millipoises;
- (b) a dosage amount of a therapeutic drug liquid formulation in the capsule lumen;
- (c) a hydroactivated composition on the outside wall of the capsule;
- d) a semipermeable composition surrounding the hydroactivated composition;
- and,
- e) a passageway that communicates the exterior with the interior of the osmotic system, which passageway is formed by a process selected from the group consisting of drilling, eroding, extracting, dissolving, bursting, and leaching a passageway in the osmotic system.
An osmotic system for delivering a therapeutic drug formulation to an environment of use, wherein the osmotic system comprises:
- a) a capsule comprising a gelatin wall having a bloom value of 160 to 250 and an internal lumen;
- b) a dosage amount of a therapeutic drug liquid formulation in the capsule lumen;
- c) a hydroactivated composition on the outside wall of the capsule;
- d) a semipermeable composition surrounding the hydroactivated composition;
- e) a passageway in the osmotic system that connects the exterior with the interior of the osmotic system, and wherein;
- f) the osmotic system is shaped and adapted for admittance into a buccal, implant, anal, cervical, vaginal, subcutaneous, oral and nose environment of use.
Dependencies are inferred from the claim text.