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US 5,409,959 AGranted
Antithrombotic treatment with calix(n)arene compounds
AssigneeGenelabs Incorporated
InventorsKou M. Hwang, You M. Qi, Su-Ying Liu, Thomas C. Lee, William Choy, Jen Chen
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Abstract
A method of inhibiting thrombus formation in a mammalian subject. The method involves administering to the subject a therapeutically effective dose of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having terminal sulfonate groups, including esters and amides which are cleavable in vivo.
Claims9
A method of inhibiting thrombus formation in a mammalian subject, comprising
- administering to the subject a therapeutically effective dose of calix(n)arene compound which is derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having terminal sulfonate groups.
A method of inhibiting thrombus formation in a mammalian subject, comprising
- administering to the subject a therapeutically effective dose of a calix(n)arene compound having the general structure:
- ##STR4## wherein (a) n=4, 6, or 8;
- (b) R.sub.1 is OH, .dbd.O, or a combination thereof;
- (c) R.sub.2 has the form:
- (CH.sub.2).sub.m R.sub.2 ', where m=1-3, and R.sub.2 ' is a sulfonate group;
- (d) R.sub.4 is >CH.sub.2, .gtoreq.CH, or a combination thereof.
3 more elements
Dependencies are inferred from the claim text.