Liposomes comprising aminoglycoside phosphates and methods of production and use
AssigneeThe Liposome Company, Inc.
InventorsMarcel B. Bally, Lois E. Bolcsak, Pieter R. Cullis, Andrew S. Janoff, Lawrence D. Mayer
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Abstract
Aminoglycosides, analogs and derivatives thereof, in the form of phosphate salts are described as well as the process for making and utilizing same. Aminoglycoside phosphate liposomes and nonguanadino aminoglycoside phosphate liposomes, their preparation and use, are particularly described.
Claims17
Liposomes comprising at least one phoshate salt of an aminoglycoside and a lipid bilayer comprising a lipid, wherein the ratio of the aminoglycoside to the lipid (weight/weight) is at least about 1:10.
A method of preparing a composition comprising at least one phosphate salt of an aminoglycoside in association with a liposome comprising the steps of:
- (a) dispersing an aminoglycoside phosphate in an aqueous phase;
- and
- (b) combining said aqueous phase with a lipid under conditions adapted to the formation of a liposome comprising said lipid and adapted to the association of said aminoglycoside with said lipid in said liposome, wherein
- the ratio of the aminoglycoside to the lipid in the liposome (weight/weight) is at least about 1:10.
A method of treating animals, including humans, comprising administration of a therapeutically effective amount of an aminoglycoside phosphate salt wherein said aminoglycoside phosphate salt is associated with a liposome, wherein the liposome comprises a lipid bilayer comprising a lipid and wherein the ratio of the aminoglycoside phosphate to the lipid in the liposome (weight/weight) is at least about 1:10.
Dependencies are inferred from the claim text.