Process for separating a radionuclide from solution
AssigneeThe Curators of the University of Missouri
InventorKurt R. Zinn
Life of this patent
Estimating the term…
Abstract
A process for separating a radionuclide such as radioactive Cu-64 from a mixture containing the radionuclide and a precursor element from which the radionuclide is formed. A weak acid solution is prepared which contains the mixture of the radionuclide and the element. The solution is contacted with a ligand which preferentially forms a complex with the radionuclide relative to the precursor element. The radionuclide complexed to the ligand is separated from the precursor element and released from the ligand by contacting the ligand with an acid.
Claims20
A process for separating a radionuclide from a mixture containing the radionuclide and a precursor element of the radionuclide in which the mass of the precursor element is at least about 100 times the mass of the radionuclide, comprising:
- (a) preparing a weak acid solution which contains the mixture of the radionuclide and the element,
- (b) contacting the solution with a ligand which preferentially forms a complex with the radionuclide relative to the precursor element, the percentage of the radionuclide which is complexed by the ligand, as a percentage of the total radionuclide in the mixture, being on the order of at least about 100 times the percentage of the precursor element which is complexed by the ligand, as a percentage of the total precursor element in the mixture,
- (c) separating the radionuclide complexed to the ligand from the precursor element, and
- (d) releasing the radionuclide from the ligand.
A process for separating a copper radionuclide from a mixture containing the copper radionuclide and a zinc precursor element of the copper radionuclide in which the mass of the zinc precursor element is at least about 100 times the mass of the copper radionuclide, comprising:
- (a) preparing a weak acid solution which contains the mixture of the copper radionuclide and the zinc precursor element,
- (b) contacting the solution with a ligand which preferentially forms a complex with the copper radionuclide relative to the zinc precursor element, the percentage of the radionuclide which is complexed by the ligand, as a percentage of the total radionuclide in the mixture, being on the order of at least about 100 times the percentage of the precursor element which is complexed by the ligand, as a percentage of the total precursor element in the mixture,
- (c) separating the copper radionuclide complexed to the ligand from the zinc precursor element, and
- (d) releasing the copper radionuclide from the ligand.
A process for producing a radionuclide adapted for radiation therapy or diagnosis of a mammal by separating a copper radionuclide from a mixture of copper radionuclide and a zinc precursor element comprising:
- (a) forming a solution in weak acid which contains the mixture of copper radionuclide and zinc precursor element, said copper radionuclide resulting from fast neutron capture by a zinc target, said solution having a pH in the range of about 2.3 to 3.1,
- (b) contacting the solution with a ligand immobilized on a resin, which ligand preferentially forms a complex with the copper radionuclide relative to the zinc precursor element, the percentage of the radionuclide which is complexed by the ligand, as a percentage of the total radionuclide in the mixture, being on the order of at least about 100 times the percentage of the precursor element which is complexed by tile ligand, as a percentage of the total precursor element in the mixture, such that at least about 80% of the concentration of the radionuclide is complexed by the ligand and less than about 1% of the precursor element is complexed by the ligand,
- (c) separating the copper radionuclide complexed to the ligand from the zinc precursor element, and
- (d) releasing the copper radionuclide from the ligand by contacting the ligand with an acid to form a copper radionuclide containing eluate, and
- (e) removing residual zinc precursor element from the eluate.
Dependencies are inferred from the claim text.