Gel composition for implant prosthesis and method of use
AssigneeCytRx Corporation
InventorsDaiva K. Tautvydas, Mannarsamy Balasubramanian, R. Martin Emanuele
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Abstract
In accordance with the present invention, a composition and method is provided for a biocompatible filler for prostheses. The composition and method relate to certain polyoxyethylene/polyoxypropylene block copolymers which have gelling properties at body temperature and are ideally suited for use as fillers for a soft tissue prosthesis such as a breast implant.
Claims16
A method for providing a prosthesis approximating the consistency of human or animal tissue comprising the step of filling the lumen of the prosthesis with an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O).sub.a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O).sub.b constitutes from about 50 to 90 percent by weight of the copolymer.
A soft tissue prosthesis [with]comprising a lumen and a filler, wherein the filler comprises an aqueous solution of a polyoxyethylene-polyoxypropylene block copolymer having the following formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O).sub.a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O).sub.b constitutes from about 50 to 90 percent by weight of the copolymer.
A method of implanting a prosthesis into a human or animal comprising the steps of:
- implanting the lumen of the prosthesis into the body of the human or animal;
- filling the lumen with an aqueous solution of polyoxyethylene-polyoxypropylene block copolymer having the following formula:
- HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H
- wherein a is an integer such that the hydrophobe represented by (C.sub.3 H.sub.6 O).sub.a has a molecular weight of between 1750 and 6000 daltons and b is an integer such that the hydrophile portion represented by (C.sub.2 H.sub.4 O).sub.b constitutes from about 50 to 90 percent by weight of the copolymer;
- and,
- allowing the solution to gel.
Dependencies are inferred from the claim text.