Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
AssigneeThe United States of America as represented by the Secretary of Health and Human Services
InventorsLarry K. Keefer, Joseph A. Hrabie
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Abstract
A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.
Claims22
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone, wherein said polymeric backbone is of a polymer selected from the group consisting of a polyolefin, a polyether, a polyester, a polyamide, a polyurethane, a peptide, and a starburst dendrimer, and at least one nitric oxide-releasing [N.sub.2 O.sub.2 ] functional group selected from the group consisting of X--N(O)NO] or [N(O)NO--X, wherein X is an organic moiety covalently bonded to said [N.sub.2 O.sub.2 ], and wherein the [N.sub.2 O.sub.2 ] group is covalently bonded in said polymer through said organic moiety X.
A polymer capable of releasing nitric oxide, said polymer comprising a polymeric backbone of polyethyleneimine and at least one nitric oxide releasing group having the formula [N2O.sub.2 ] covalently bonded thereto.
Dependencies are inferred from the claim text.