Method for preparing fibrinogen adhesive from whole blood
OwnerGordon H. Epsteininventor
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Abstract
A process and apparatus for one-step preparation of the fibrinogen component of an adhesive is described. The fibrinogen is precipitated directly from plasma using polyethylene glycol. This permits preparation of autologous fibrinogen from the patient during surgery which can be combined with calcium, ion and thrombin and used as an adhesive.
Claims7
A process for preparing a fibrinogen adhesive composition from whole blood which consists essentially of:
- contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW200-8000 daltons) effective to precipitate said fibrinogen adhesive composition;
- recovering the precipitated fibrinogen adhesive composition;
- and
- suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
A method of cementing tissues with a fibrinogen adhesive comprising applying to said tissues an amount of said adhesive effective to cement said tissues, comprising thrombin, calcium ions, and a fibrinogen adhesive composition prepared from whole blood by a process consisting essentially of:
- contacting plasma, which has been removed from said whole blood, with an amount of polyethylene glycol (PEG) (MW 200-8000 daltons) effective to precipitate said fibrinogen adhesive composition;
- recovering the precipitated fibrinogen adhesive composition;
- and
- suspending said precipitated fibrinogen adhesive composition in an aqueous medium.
Dependencies are inferred from the claim text.