Method for determining adequacy of dialysis based on urea concentration
AssigneeRaja N. Khuri
InventorsRaja N. Khuri, Nazih L. Nakhoul
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Abstract
A method for determining the adequacy of dialysis, using determination of urea concentration in the dialysate effluent with an enzymatic electrode incorporating a urease sensor, and conversion of this information to arterial urea nitrogen utilizing a "flow ratio" correction; and utilizing the arterial blood urea nitrogen derived from readings of an on-line monitoring sensor as an absolute quantity, and the urea reduction ratio as a relative quantity as a new end-point for dialysis adequacy.
Claims5
A method for determining adequacy of dialysis of a patient, comprising:
- (a) providing an enzymatic urease-based sensor;
- (b) using said sensor to determine a concentration of urea in dialysate from said dialysis;
- (c) utilizing said urea concentration in said dialysate and selected physiological factors associated with the patient and with said dialysis to accurately determine a concentration of urea in arterial blood and to determine dialysis adequacy;
- and
- (d) ceasing dialysis of said patient when said dialysis is adequate as determined in step (c).
A method for determining adequacy of dialysis of a patient, comprising:
- (a) providing an enzymatic urease-based sensor;
- (b) using said sensor to determine a concentration of urea in dialysate from said dialysis;
- (c) utilizing said urea concentration in said dialysate and selected physiological factors associated with the patient and with said dialysis to accurately determine a concentration of urea in arterial blood and to determine dialysis adequacy;
- (d) calculating a urea reduction ratio;
- (e) utilizing the dialysis adequacy as an absolute quantity and the urea reduction ratio as a relative quantity as new end-points to determine when to cease dialysis;
- and
- (f) ceasing dialysis of said patient when said dialysis is adequate as determined in step (c) and step (e).
A method for determining adequacy of dialysis of a patient, comprising:
- (a) providing an enzymatic urease-based sensor electrode;
- (b) using said electrode to determine a concentration of urea in dialysate from said dialysis;
- (c) utilizing said urea concentration in said dialysate to obtain an arterial urea concentration;
- (d) using said arterial urea concentration to obtain a profile of urea reduction;
- (e) using said profile to assess dialysis adequacy;
- (f) calculating a urea reduction ratio;
- (g) utilizing the dialysis adequacy as an absolute quantity and the urea reduction ratio as a relative quantity to determine when to cease dialysis;
- and
- (h) ceasing dialysis of said patient when said dialysis is adequate as determined in steps (e) and (g).
Dependencies are inferred from the claim text.