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US 5,403,845 AGranted
Muscarinic agonists
AssigneeThe University of Toledo
InventorsPhilip G. Dunbar, Graham J. Durant, Wayne P. Hoss, William S. Messer, Jr.
Life of this patent
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Abstract
Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6 -tetrahydropyrimidine compositions and substituted 3,4,5,6 -tetrahydropyridine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for example, treating the symptoms of cognitive disorders, especially impaired memory, which are associated with decreased acetylcholine synthesis and cholinergic cell degeneration.
Claims19
A compound having the formula (i), (ii), or (iii) below or a pharmaceutically acceptable salt thereof, ##STR4## wherein:
- A is H or NHR;
- R is H, alkyl of 1-7 carbon atom, --C(O)--R.sup.1 or C(O)OR.sup.1 ;
- and wherein Z is ##STR5## wherein X is O or S, and wherein R.sup.1 is a monovalent hydrocarbon radical having 1-7 carbon atoms, R.sup.2 is alkyl of 1-8 carbon atoms, alkylthionlkyl or alkoxyalkyl of up to 8 carbon atoms or NHR, R.sup.3 is H or --CH.sub.3, R.sub.4, is H or an alkyl of 1-8 carbon atoms and wherein R.sup.5 is H, alkyl of 1-8 carbon atoms, alkoxy of 1-8 carbon atoms or an alkylthio group of 1-8 carbon atoms.
Dependencies are inferred from the claim text.