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US 5,401,861 AGranted
Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
AssigneeEli Lilly and Company
InventorTa-Sen Chou
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Abstract
A stereoselective process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates by contacting a lactol with an amine base in an inert solvent, adjusting the temperature and adding a sulfonating reagent.
Claims14
A stereoselective low temperature process for preparing an alpha-anomer enriched ribofuranosyl derivative of the formula ##STR3## wherein each X is independently selected from hydroxy protecting groups and Y is selected from the group consisting of alkylsulfonate alkylsulfonate comprising contacting a lactol of the formula ##STR4## wherein X is as defined above;
- with an amine base in an inert solvent;
- lowering the temperature of the lactol solution in the range of about -40.degree. C. to about -120.degree. C. then adding a sulfonating reagent.
Dependencies are inferred from the claim text.