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US 5,401,852 AGranted
Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
AssigneeZambon Group S.p.A.
InventorsMarco Villa, Claudio Giordano, Silvia Cavicchioli, Silvio Levi
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Abstract
Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like chloramphenicol, Thiamphenicol and Florfenicol.
Claims3
A compound of formula ##STR11## wherein R.sub.2 represents a lower alkyl, dichloromethyl, phenyl, alkoxy or benzyloxy group;
- R.sub.5 and R.sub.6 together are the group C (R.sub.3) (R.sub.4)--wherein R.sub.3 and R.sub.4, equal to or different from each other, represent hydrogen atoms, lower alkyls, phenyls, lower alkoxy or R.sub.3 and R.sub.4 together are an oxygen atom, sulphur atom or a tetra or pentamethylene chain;
- and R.sub.7 represents a hydrogen atom.
Dependencies are inferred from the claim text.