Injectable compositions of a cephalosporin dihydrate salt
AssigneeBristol-Myers Squibb Company
InventorsMunir N. Nassar, Murray A. Kaplan
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Abstract
The present invention provides physical admixtures of a new crystalline dihydrochloride dihydrate salt of the cephalosporin antibiotic, cefepime with a pharmaceutically acceptable non-toxic organic or inorganic base. In particular, this invention provides physical admixtures having a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having a specific X-ray powder diffraction pattern as described herein.
Claims3
A temperature and moisture stable crystalline dihydrochloride dihydrate salt of 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylate in a vacuum-dried physical admixture with a pharmaceutically acceptable non-toxic organic or inorganic base selected from the group consisting of sodium salts with weak non-toxic anions, N-methylglucamine and L(+) arginine in proportions to provide a pH of about 3.5 to about 7 on dilution of the admixture with water to injectable concentration.
Dependencies are inferred from the claim text.