Dibenzofuranyl N-alkyl carbamates
AssigneeAmerican Home Products Corporation
InventorsThomas J. Commons, Richard E. Mewshaw, Donald P. Strike
Life of this patent
Estimating the term…
Abstract
A compound of formula A: ##STR1## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO.sub.2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, alkoxycarbonyloxy, mono or dialkylaminocarbonyl, or mono or dialkylaminocarbonyloxy; R.sup.3 is hydrogen or alkyl; R.sup.4 is alkyl, cycloalkylalkyl or phenylalkyl or substituted phenylalkyl, and the substituent on the benzene ring is alkyl, alkoxy, halo, nitro, cyano, trifluoromethyl or phenyl, are anti-cholesterolemic agents.
Claims10
A compound of formula A:
- ##STR6## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, --CO.sub.2 H, C.sub.2 -C.sub.7 alkylcarbonyl, C.sub.2 -C.sub.7 alkylcarbonyloxy, C.sub.2 -C.sub.7 alkoxycarbonyl, C.sub.2 -C.sub.7 alkoxycarbonyloxy, mono or di alkylaminocarbonyl in which each alkyl group has 1 to 6 carbon atoms, or mono or di alkylaminocarbonyloxy in which each alkyl group has 1 to 6 carbon atoms;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.4 is C.sub.2 -C.sub.18 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 8 carbon atoms and the alkyl moiety has 1 to 6 carbon atoms or phenylalkyl of 7 to 18 carbon atoms or substituted phenylalkyl, where the alkyl moiety is 1 to 12 carbon atoms and the substituent on the benzene ring is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, nitro, cyano, trifluoromethyl or phenyl.
A method for reducing cholesterol uptake from the intestinal tract which comprises administering, orally or parenterally, to an animal in need of reduced cholesterol absorption, a compound of formula B:
- ##STR7## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, --CO.sub.2 H, C.sub.2 -C.sub.7 alkylcarbonyl, C.sub.2 -C.sub.7 alkylcarbonyloxy, C.sub.2 -C.sub.7 alkoxycarbonyl, C.sub.2 -C.sub.7 alkoxycarbonyloxy, mono or di alkylaminocarbonyl in which each alkyl group has 1 to 6 carbon atoms, or mono or di alkylaminocarbonyloxy in which each alkyl group has 1 to 6 carbon atoms;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.4 is C.sub.2 -C.sub.18 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 8 carbon atoms and the alkyl moiety has 1 to 6 carbon atoms or phenylalkyl of 7 to 18 carbon atoms or substituted phenylalkyl, where the alkyl moiety is 1 to 12 carbon atoms and the substituent on the benzene ring is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, nitro, cyano, trifluoromethyl or phenyl.
A pharmaceutical composition comprising a compound of formula B:
- ##STR8## wherein R.sup.1 and R.sup.2 are, independently, hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, --CO.sub.2 H, C.sub.2 -C.sub.7 alkylcarbonyl, C.sub.2 -C.sub.7 alkylcarbonyloxy, C.sub.2 -C.sub.7 alkoxycarbonyl, C.sub.2 -C.sub.7 alkoxycarbonyloxy, mono or di alkylaminocarbonyl in which each alkyl group has 1 to 6 carbon atoms, or mono or di alkylaminocarbonyloxy in which each alkyl group has 1 to 6 carbon atoms;
- R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- R.sup.4 is C.sub.2 -C.sub.18 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 8 carbon atoms and the alkyl moiety has 1 to 6 carbon atoms or phenylalkyl of 7 to 18 carbon atoms or substituted phenylalkyl, where the alkyl moiety is 1 to 12 carbon atoms and the substituent on the benzene ring is alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halo, nitro, cyano, trifluoromethyl or phenyl;
- and a pharmaceutically acceptable carrier therefore.
Dependencies are inferred from the claim text.