Heterocyclic compounds

A thiazoline derivative of the formula:

• ##STR116## wherein R represents the general formula:
• G--E--D--B--A--
• wherein A represents a linkage which contains no atom, an alkylene group of from 1 to 6 carbon atoms(s), an alkenylene group of from 2 to 6 carbon atoms, a group of the formula:
• ##STR117## wherein Y represents an alkylene group of from 1 to 4 carbon atom(s) or an alkenylene group of from 2 to 4 carbon atoms, a saturated hydrocarbon ring of from 4 to 7 carbon atoms or a heterocyclic mono ring containing 3 to 7 ring members including 1 or 2 hetero atom(s) selected from N, O and S atoms which may be partially or fully saturated or aromatic,
• B represents a linkage which contains no atom or an alkylene group of from 1 to 6 carbon atom(s),
• D represents a linkage which contains no atom, an oxygen atom, a carbonyl group or a group of the formula:
• --NR.sup.1 --CO-- or --CO--NR.sup.1 --
• wherein R.sup.1 represents a hydrogen atom, an alkyl group of from 1 to 6 carbon atom(s), a phenyl group or a benzyl group,
• E represents a linkage which contains no atom, an alkylene group of from 1 to 8 carbon atom(s) or an alkylene group of from 1 to 8 carbon atom(s) substituted by a phenyl or benzyl group,
• G represents a mono-, bi- or tri-carbocyclic ring(s) containing not more than 15 carbon atoms which may be partially or fully saturated or aromatic, or a mono-, bi- or tri-heterocyclic ring(s) containing not more than 15 ring members including carbon and 1 or 2 hetero atoms selected from N, O and S atoms which may be partially or fully saturated or aromatic wherein said carbocyclic or heterocyclic ring(s) represented by G is unsubstituted or substituted by 1-3 of an alkyl group of from 1 to 6 carbon atoms(s), an alkoxy group of from 1 to 6 carbon atom(s), a halogen atom, a trifluoromethyl group or a nitro group,
• L represents a group of the formula:
• --CO--COR.sup.2
• --CO--CH.sub.2 --COR.sup.2
• --CO--CF.sub.2 --COR.sup.2
• --CO--CO--NR.sup.5 R.sup.6
• or
• --CO--CH.sub.2 --CO--NR.sup.5 R.sup.6
• wherein, R.sup.2 represents a hydrogen atom, a hydroxy group, an alkyl group of from 1 to 6 carbon atom(s), an alkoxy group of from 1 to 6 carbon atom(s), a phenyl group, an alkyl group of from 1 to 6 carbon atom(s) substituted by a phenyl group, or an alkoxy group of from 1 to 6 carbon atom(s) substituted by a phenyl group, R.sup.5 and R.sup.6 independently represents a hydrogen atom, an alkyl group of from 1 to 6 carbon atom(s), a phenyl group, or an alkyl group of from 1 to 6 carbon atom(s) substituted by a phenyl group, with the proviso that compounds wherein both of A and B are a linkage which contains no atom are excluded, or a non-toxic salt or hydrate thereof.