Nimodipine enhanced growth and vascularization of neural grafts
AssigneeMiles Inc.
InventorsStephen B. Dunnett, Stanley Finger
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Abstract
The invention relates to a method of enhancing vascularization and growth of neural grafts in warm-blooded animals, especially man, comprising administering an effective amount of the nimodipine, a calcium channel blocker, having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(.beta.-methoxyethy l ester)-5-(isopropyl ester) to the animals to achieve such enhancement and growth. The method enhances the survival rate of transplantations.
Claims10
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising administering an effective amount of nimodipine to said animal to achieve such enhancement and growth.
A method of enhancing vascularization and growth of neural grafts in a warm-blooded animal comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(.beta.-methoxyethy l ester)-5-(isopropyl ester) prior to transplantation.
A method of enhancing the viability of neural graft tissue, comprising soaking or perfusing neural graft tissue in an effective amount of nimodipine having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl-pyridine-3-(.beta.-methoxyethyl ester)-5-(isopropyl ester) prior to transplantation.
Dependencies are inferred from the claim text.