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US 5,401,758 AGranted
Pyridinyl cyanoguanidine compounds
AssigneeBristol-Myers Squibb Company
InventorsKarnail S. Atwal, Francis N. Ferrara
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Abstract
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 to R.sup.4 and n are as defined herein and X is O, S or NCN. These compounds have potassium channel opening activity and are useful, therefore for example, as cardiovascular agents.
Claims6
A compound of the formula ##STR7## or pharmaceutically acceptable salts thereof wherein X is O, S or NCN;
- R.sup.1 is pyridinyl;
- R.sup.2 is hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, arylalkyl, (cycloalkyl)alkyl, --CN, --NO.sub.2, --COR, --COOR, --CONHR, --CONR.sup.5, --CF.sub.3, --S--alkyl, --SOalkyl, --SO.sub.2 alkyl, halogen, amino, substituted amino, hydroxy, --O--alkyl, --OCF.sub.3, --OCH.sub.2 CF.sub.3, --OCOalkyl, --OCONRalkyl, --NRCOalkyl, --NRCOOalkyl or --NRCONR.sup.5, where R is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl;
- R.sup.3 and R.sup.4 are independently hydrogen, alkyl, aryl or arylalkyl;
- or R.sup.3 and R.sup.4 taken together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring;
- R.sup.5 is hydrogen, hydroxy or --OCOR;
- and
- n is 0 or the integer 1 or 2.
4 more elements
Dependencies are inferred from the claim text.