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US 5,401,748 AGranted
2,14-disubstituted ergolines, their production and use in pharmaceutical compositions
AssigneeSchering Corporation
InventorsGerhard Sauer, Helmut Wachtel, Peter A. Loschmann
Life of this patent
Estimating the term…
Abstract
2,14-Disubstituted ergolines of formula I ##STR1## in which R, R.sup.2, R.sup.6, R.sup.14 and X have the meaning named in the application, as well as their production and use in pharmaceutical agents, are described.
Claims4
A compound of formula I ##STR5## wherein R.sup.2 is C.sub.1-4 alkyl,
- R.sup.6 is C.sub.1-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-5 cycloalkyl-C.sub.1-2 alkyl,
- X is oxygen or sulfur,
- R.sup.14 is C.sub.1-6 alkyl, --CO--R.sup.3 pr CR.sup.4 R.sup.5 OH and R.sup.3, R.sup.4 and R.sup.5 each are hydrogen or C.sub.1-5 alkyl, and
- R is N(C.sub.2 H.sub.5).sub.2, SCH.sub.3, hydrogen or C.sub.1-7 alkyl optionally substituted by methoxy, acetoxy, or halogen, or a diastereomer or acid addition salt thereof.
1 more element
The compound selected from the group consisting of
- 8.alpha.-(3,3-Diethylureido)-2-methyl-6-propyl-ergoline-14-carbaldehyde,
- 3-(14-ethyl-2-methyl-6-propyl-8.alpha.-ergolinyl)-1,1-diethylurea,
- 3-(2,14-dimethyl-6-propyl-8.alpha.-ergolinyl)-1,1-diethylurea,
- 1,1-diethyl-3-(2,6-dimethyl-14-ethyl-8.alpha.-ergolinyl)-urea,
- 3-(14-ethyl-2-methyl-6-propyl-8.alpha.-ergolinyl)-1,1-diethylurea,
- N-(2,14-dimethyl-6-n-propyl-8.alpha.-ergolinyl)-methoxyacetamide,
- N-(2,14-dimethyl-6-n-propyl-8.alpha.-ergolinyl)-trifluoroacetamide
- N-(2,14-dimethyl-6-n-propyl-8.alpha.-ergolinyl)-ethyl-methylbutyric acid amide,
- N-(2,14-dimethyl-6-n-propyl-8.alpha.-ergolinyl)-thioformamide and
- N-(2,14-dimethyl-6-n-propyl-8.alpha.-ergolinyl)-dithiocarbamic acid methyl ester.
7 more elements
Dependencies are inferred from the claim text.