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US 5,401,746 AGranted
Substituted pyridines heptenoic acid derivatives, useful for treating arterioscleros, lipopotaemia and the like
AssigneeBayer Aktiengesellschaft
InventorsRolf Angerbauer, Peter Fey, Walter Hubsch, Thomas Philipps, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
Life of this patent
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Abstract
Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings, X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and R is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl and R.sup.22 --denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products.
Claims5
A substituted pyridine of the formula:
- ##STR234## wherein A represents phenyl or phenyl which is monosubstituted or disubstituted by a substituent selected from the group consisting of methyl, hydroxymethyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, methoxy, ethoxy, propoxy, isopropoxy, phenoxy, benzyloxy, fluorine, chlorine or trifluoromethyl;
- B represents cyclopropyl, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, or tert.-butyl;
- E represents methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, pentyl, isopentyl, hexyl or isohexyl;
- and
- R.sup.22 represents hydrogen, lower alkyl, phenyl, benzyl or a physiologically tolerable metal or ammonium cation.
2 more elements
Dependencies are inferred from the claim text.