2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
AssigneesYoshitomi Pharaceutical Industries, Ltd., Yamasa Shoyu Kabushiki Kaisha
InventorsTohru Ueda, Takuma Sasaki, Akira Matsuda, Keiji Yamagami, Akihiro Fujii
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Abstract
2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, compositions containing one or more of these compounds and methods for production of these compounds are disclosed. Said compounds and salts thereof exhibit noticeable antitumor activities.
Claims1
A method of treating a patient having a tumor, which comprises administering to the patient an effective anti-tumor amount of a 2'-methylidenepyrimidine nucleoside selected from the group consisting of (1) a compound of the formula ##STR6## wherein R.sup.3 is hydrogen, (2) a salt of said compound and (3) a hydrate of said compound.
Dependencies are inferred from the claim text.