Glycoconjugate inhibition of Streptococcus pyrogenes adhesion
AssigneesColgate-Palmolive Company, Forsyth Dental
InventorsAbdul Gaffar, Ronald Gibbons, Stanislawa Tylewska
Life of this patent
Estimating the term…
Abstract
Enhancement of the method and oral compositions for inhibiting adherence of Streptococcus pyogenes to pharyngeal and oral mucosa cells by treating these areas with a glycoconjugate comprising an oligosaccharide linked to a carrier. The oligosaccharide should have at least one fucose moiety or a galatose moiety which is free of digalactose and N-acetylneuraminyl lactose. The carrier may include albumins, starch or synthetic polymers.
Claims13
A method of inhibiting adherence of Streptococcus pyogenes to epithelial pharyngeal and oral cells comprising contacting said cells in the oral cavity with an oligosaccharide which is conjugated to a protein, a synthetic polymer or starch.
A method of preventing or treating a sore throat caused by Streptococcus pyogenes comprising applying to the soft mucosal surface of the throat an oligosaccharide which is conjugated to a protein, a synthetic polymer or starch which inhibits the adherence of said bacteria to said surface.
A method of inhibiting the adherence of Streptococcus pyogenes to the oral or pharyngeal mucosa comprising applying a oligosacchride which is conjugated to a protein, a synthetic polymer or starch thereto.
An oral composition comprising an orally acceptable vehicle and an oligosaccharide which is conjugated to a protein, a synthetic polymer or starch, the oligosaccaride-conjugate being in an amount to effectively inhibit the adherence of Streptococcus pyogenes to oral or pharyngeal mucosa or the cells thereof.
Dependencies are inferred from the claim text.