Acid-resistant FGF composition for treating ulcerating diseases of the gastrointestinal tract
AssigneesTakeda Chemical Industries, Ltd., Children's Medical Center Corporation
InventorsMoses J. Folkman, Koichi Kato
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Abstract
This invention describes pharmaceutical compositions and methods of treating ulcerating diseases of the gastrointestinal tract in mammals with an acid-resistant fibroblast growth factor compositions. Also described is the use of acid-resistant fibroblast growth factor compositions in the treatment of various other fibroblast growth factor-responsive conditions.
Claims5
A pharmaceutical composition for ulcerating diseases of the gastrointestinal tract which comprises FGF, an antisecretory agent and a pharmaceutically acceptable carrier, wherein the ratio of the antisecretory agent to FGF by weight is between 0.1 to 100.
A pharmaceutical composition for ulcerating diseases of the gastrointestinal tract which comprises acid-resistant FGF, an antisecretory agent and a pharmaceutically acceptable carrier, wherein the ratio of the antisecretory agent to acid-resistant FGF by weight is between 0.1 to 100.
A pharmaceutical composition for ulcerating diseases of the gastrointestinal tract which comprises FGF or acid-resistant FGF, an antisecretory agent and a pharmaceutically acceptable carrier, wherein the ratio of antisecretory agent to FGF by weight is between 0.1 to 100 and wherein the antisecretory agent is selected from the group of cimetidine or ranitidine.
A pharmaceutical composition for ulcerating diseases of the gastrointestinal tract, which comprises FGF, an antisecretory agent and a pharmaceutically acceptable carrier, wherein the amount of FGF is about 10-300 .mu.g, and the amount of the antisecretory agent is about 20-600 mg.
A pharmaceutical composition for ulcerating diseases of the gastrointestinal tract comprising about 10-300 .mu.g of FGF, about 0.5-5 g of sucralfate and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.