Reagent for coagulating blood
AssigneeToa Medical Electronics Co., Ltd.
InventorMasaru Yonemura
Life of this patent
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Abstract
A reagent blood coagulation that causes an increase in turbidity changes when added to a plasma sample containing a substance activating coagulation factor activating such as tissue thromboplastin, phospholipid and thrombin, calcium ion, and molecular substance such as high molecular vinyl and a high molecular polysaccharide. By adding a molecular substance to the reagent, the turbidity change due to blood coagulation is increased, and hence the changing quantity of transmitted light or scattered light increases, thereby making it possible to achieve a more accurate detection. Besides, by adjusting the electric conductivity, pH and osmotic pressure to proper values, the turbidity change due to blood coagulation may be further amplified.
Claims12
A blood coagulating reagent that causes an increase in turbidity changes when added to a plasma sample, comprising:
- a substance activating coagulation factor selected from the group consisting of tissue thromboplastin, phospholipid and thrombin,
- calcium ion, and
- a high molecular substance with a molecular weight of at least 1000 for complicating intertwinement of fibrin fibers in a final stage of a coagulating reaction, wherein electrical conductivity is adjusted in the range of 4.0 to 15.0 mS, pH is adjusted in the range of 6.7 to 8.2 and osmotic pressure is adjusted in the range of 100 to 700 mOsm/kg.
Dependencies are inferred from the claim text.