2-methyl-4-hexene-and 3-methyl-5-heptene-1,2-diol derivatives
AssigneeSyntex (U.S.A.) Inc.
InventorsDariush Davalian, Cheng-I Lin, Edwin F. Ullman
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Abstract
2-methyl-4-hexene- and 3-methyl-5-heptene-l,2-diol derivatives are disclosed together with methods for preparing such derivatives. Where the derivative is a 2-methyl-4-nexene- or 3-methyl-5-heptene-l,2-diol conjugated to a label, the conjugates are useful in immunoassays. Where the 2-methyl-4-hexene or 3-methyl-5-heptene-l,2-diol is conjugated to an immunogenic carrier, the conjugates may be employed as an immunogen for use in the preparation of antibodies. The label conjugate and the antibodies can be utilized in an immunoassay for the determination or detection of cyclosporin in a sample suspected of containing cyclosporin.
Claims29
A compound of the formula:
- ##STR10## wherein:
- X is a linking group of 0-65 atoms not counting hydrogen, said atoms being independently selected from the group consisting of O, S, P, N, Si, C and halogen,
- Z is a luminescent label, a group of molecular weight greater than 5000 which is an immunogenic carrier or an enzyme, or a ligand, or a hapten;
- Y is oxygen or sulfur;
- and
- n is a number from 1 up to the molecular weight of Z divided by 1000;
- and including the optically active isomers thereof.
A compound of the formula:
- ##STR11## wherein:
- X.sub.1 is a linking group of 0 to 35 atoms not counting hydrogen, which atoms are each independently selected from the group consisting of carbon, oxygen, nitrogen, and sulfur, wherein X.sub.1 is bonded to O through a carbon atom;
- Z.sub.1 is a poly(amino acid) of molecular weight greater than 5000 which is an antigen or an enzyme;
- n.sub.1 is a number from 1 up to the molecular weight of Z.sub.1 divided by 1000;
- including the optically active isomers thereof.
A compound of the formula:
- ##STR12## wherein:
- W.sub.1 is O, S, or NH;
- m is 0 to 10;
- Z.sub.2 is a poly(amino acid) of molecular weight greater than 5000 which is an antigen or an enzyme;
- n.sub.2 is a number from 1 up to the molecular weight of Z.sub.2 divided by 1000;
- including the optical isomers thereof,
Dependencies are inferred from the claim text.