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US 5,401,648 AGranted
Peptides having peptidyl transferase inhibiting activity and methods of use thereof
AssigneeUniversity of Maryland, College Park
InventorPaul S. Lovett
Life of this patent
Estimating the term…
Abstract
5-mer and 8-mer polypeptides have been demonstrated to inhibit peptidyl transferase and according constitutes synthetic antibiotics. Identified, sequence-specific peptides effective include Met-Val-Lys-Thr-Asp (SEQ ID NO: 1), Met-Lys-Lys-Ala-Asp (SEQ ID NO: 2), Met-Lys-Lys-Ser-Glu (SEQ ID NO: 3) and Met-Ser-Thr-Ser-Lys-Asn-Ala-Asp (SEQ ID NO: 4) The polypeptides can be used as antibiotics, alone or together with a carrier.
Claims6
A purified preparation of an amino acid sequence selected from the group consisting of
- Met-Val-Lys-Thr-Asp, (SEQ ID NO:
- 1)
- Met-Lys-Lys-Ala-Asp, (SEQ ID NO:
- 2)
- Met-Lys-Lys-Ser-Glu (SEQ ID NO:
- 3) and
- Met-Ser-Thr-Ser-Lys-Asn-Ala-Asp (SEQ ID NO:
- 4).
5 more elements
A 5-mer polypeptide having the sequence
- Met-Val-Lys-Thr-Asp (SEQ ID NO:
- 1),
- Met-Lys-Lys-Ala-Asp (SEQ ID NO:
- 2) or
- Met-Lys-Lys-Ser-Glu (SEQ ID NO:
- 3).
3 more elements
An 8-mer polypeptide having the sequence
- Met-Ser-Thr-Ser-Lys-Asn-Ala-Asp (SEQ ID NO:
- 4).
Dependencies are inferred from the claim text.