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US 5,401,516 AGranted
Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
AssigneeEmisphere Technologies, Inc.
InventorsSam J. Milstein, Evgueni N. Barantsevitch
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Abstract
Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described.
Claims24
A method for preparing a modified hydrolyzed vegetable protein microsphere comprising the steps of:
- (a) mixing a hydrolyzed vegetable protein with an aqueous alkaline solution to form a solution;
- (b) treating said solution with an amine reactive agent to form a mixture containing a modified hydrolyzed vegetable protein;
- (c) recovering said modified hydrolyzed vegetable protein;
- (d) incubating said modified hydrolyzed vegetable protein in a aqueous acid solution to form said modified hydrolyzed vegetable protein microspheres;
- and
- (e) collecting said protein microspheres.
3 more elements
The method according to claim 13, wherein said microspheres are hollow and said biologically-active agent is encapsulated therein.
Dependencies are inferred from the claim text.