Solid, fast-soluble pharmaceutical preparation containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine
AssigneeSpirig AG, Pharmazeutische Praeparate
InventorsRolf-Dieter Juch, Gerd Birrenbach, Christian Pflugshaupt
Life of this patent
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Abstract
The compact, solid drug preparation, which contains N-acetylcysteine and/or S-(carboxymethyl)-L-cysteine, is suitable, despite small amounts of inactive ingredients, both for swallowing and for sucking or dissolving in water or an aqueous solution. The compactness of the drug preparation is guaranteed by a high proportion of active ingredients--more than 50% of the total weight--and by a suitable choice of a tableting adjuvant.
Claims24
An orally administered palatable, fast-soluble, (soluble in a maximum of two minutes), solid drug preparation containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine, whose proportion by weight of active ingredient is at least 50% of the total weight of the drug preparation and whose remaining amount contains as inactive ingredients at least one cellulose and/or carboxymethyl cellulose, at least one soluble sugar alcohol, at least one sweetener, at least one flavoring.
An orally administered palatable, fast-soluble, (soluble in a maximum of two minutes), solid drug preparation containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine, whose proportion by weight of active ingredient is at least 50% of the total weight of the drug preparation and whose remaining amount contains as inactive ingredients at least one cellulose, at least one soluble sugar alcohol, at least one sweetener, at least one flavoring wherein said preparation contains 100 mg of N-acetylcysteine or S-(carboxymethyl)-L-cysteine or mixtures thereof, 20 mg of microcrystalline cellulose, 30 mg of mannitol, 7.5 mg of sodium carboxymethyl cellulose, 4.5 mg of aspartame, 2.0 mg of acesulfam potassium 2.0 mg of colloidal silicic acid, 1.5 mg of magnesium stearate and 4.0 mg of lemonade flavoring.
An orally administered palatable, fast-soluble, (soluble in a maximum of two minutes), solid drug preparation containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine, whose proportion by weight of active ingredient is at least 50% of the total weight of the drug preparation and whose remaining amount contains as inactive ingredients at least one cellulose, at least one soluble sugar alcohol, at least one sweetener, at least one flavoring;
- containing 200 mg of N-acetylcysteine or S-(carboxymethyl)-L-cysteine or mixtures thereof, 40 mg of microcrystalline cellulose, 60 mg of mannitol, 15 mg of sodium carboxymethyl cellulose, 9 mg of aspartame, 4 mg of acesulfam potassium, 4 mg of colloidal silicic acid, 3 mg of magnesium stearate and 8 mg of grapefruit flavoring.
An orally administered palatable, fast-soluble, (soluble in a maximum of two minutes), solid drug preparation in swallowable tablet form containing S-(carboxymethyl)-L-cysteine and/or N-acetylcysteine, whose proportion by weight of active ingredient is at least 50% of the total weight of the drug preparation and whose remaining amount contains as inactive ingredients at least one cellulose and/or carboxymethyl cellulose, at least one soluble sugar alcohol, at least one sweetener, at least one flavoring.
Dependencies are inferred from the claim text.