Method of adsorbing pyrogens
AssigneeShinkohjinkasei Co., Ltd.
InventorsChuichi Hirayama, Keijun Hiraoka, Sunao Morimoto
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Abstract
An insoluble material for adsorbing a pyrogen comprising a polymer of an aziridine compound. According to the present invention, a large mount of the pyrogen can be easily removed from a solution containing pyrogen, and a large amount of the material for adsporbing the pyrogen can be prepared in easy steps. Therefore, the adsorbing material can greatly contribute to the preparation of medicines.
Claims21
A method of removing a pyrogen from a liquid containing said pyrogen comprising contacting said liquid with an adsorbent, which is substantially insoluble in said liquid, comprising a shaped article consisting essentially of a mixture of a first polymer consisting essentially of a polymer of an aziridine compound mixed with a second polymer selected from the group consisting of a nylon, a polyester, a polyolefin, a regenerated cellulose, a polyvinyl alcohol and a polyacrylonitrile for a time and under conditions sufficient to adsorb said pyrogen from said liquid into said adsorbent.
A method for removing a pyrogen from a liquid comprising contacting a liquid containing a pyrogen with an adsorbent, which is substantially insoluble in said liquid, comprising a shaped article consisting essentially of a mixture of a first polymer of an aziridine compound with a second polymer, selected from the group consisting of a regenerated cellulose, a polyvinyl alcohol and a polyacrylonitrile, said mixture being formed by adding said first polymer of said aziridine compound to a solution of said second polymer to form said mixture and coagulating said mixture to form said shaped article.
A method for removing a pyrogen from a liquid comprising the step of contacting a liquid containing a pyrogen with an adsorbent, which is substantially insoluble in said liquid, comprising a shaped article consisting essentially of a mixture of a first polymer of an aziridine compound with a second polymer selected from the group consisting of a nylon, a polyolefin and a polyester;
- wherein said shaped article has been prepared by melt-molding said mixture.
Dependencies are inferred from the claim text.