Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same
AssigneeMolecular Biosystems, Inc.
InventorsRolf Lohrmann, Ashwin Krishnan
Life of this patent
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Abstract
Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H,1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3",5"-di[2"',2"'-di(trifluoromethyl)3"', 3"',3"'-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.
Claims11
A compound of the general formula:
- ##STR9## wherein R is a fatty acyl group with 3-20 carbon atoms, n is 0-18 and m is 0-18.
A compound of the general formula:
- ##STR10## wherein Q is ##STR11## wherein A.sup.1, A.sup.2 and A.sup.3 are each selected from the group consisting of
- saturated and unsaturated aliphatic hydrocarbon chains,
- amine substituted saturated and unsaturated aliphatic hydrocarbon chains, and
- amide substituted saturated and unsaturated aliphatic hydrocarbon chains, and
- wherein R.sup.1, R.sup.2 and R.sup.3 have the formula:
- ##STR12## wherein R.sup.4, if present, is selected from the group consisting of Hydrogen,
- Choline,
- Ethanolamine,
- Serine,
- Glycerol,
- or myo-Inositol.
A biological or pharmaceutical compound derivatized to contain at least one group having the formula:
- ##STR13##
Dependencies are inferred from the claim text.