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AssigneeSterling Winthrop Inc.
InventorsKenneth E. Kellar, Piotr H. Karpinski, Elaine Liversidge, Wolfgang H. H. Gunther, Gregory L. McIntire, Barbara Van Orman
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This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns. In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate. In another preferred embodiment, the composition of the present invention further comprises a surfactant. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.
A method of diagnosis of an organ rich in mitochondria of a mammal comprising administering to the mammal a contrast effective amount of particles of a substantially insoluble manganese compound in the form of a manganese salt wherein said particles do not significantly alter T.sub.1 or T.sub.2 suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.
Dependencies are inferred from the claim text.