NMR contrast agents
AssigneeGuerbet
InventorsJohn P. Sadler, Charles T. Harding
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Abstract
An agent for modifying H.sub.2 O relaxation times in NMR diagnosis comprises a polysaccharide having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion. Polysaccharides include cellulose, starch, sepharose and dextran. Organic complexants include EDTA, DTPA and aminoethyl diphosphonate. A preferred metal ion is Gadolinium (III). The agents can be administered orally or parenterally.
Claims19
A method of NMR diagnosis comprising administering to a patient an effective amount for modifying relaxation time of a polysaccharide selected from the group consisting of dextrans, dextrins, starch, cellulose and agarose, having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion.
A method for visualizing the gastro-intestinal tract comprising administering by the oral route a polysaccharide selected from the group consisting of dextrans, dextrins, starch, cellulose and agarose having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion.
Dependencies are inferred from the claim text.