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US 5,401,490 AGranted
Markers of tissue hypoxia
AssigneeAlberta Cancer Board
InventorsLeonard I. Wiebe, John R. Mercer, John D. Chapman, Rezaul H. Mannan, Vijayalakashmi Somayaji
Life of this patent
Estimating the term…
Abstract
Novel nucleosides are provided having at least one hydrogen or hydroxide substitutent replaced by a .gamma.-emitting halogen. Methods of preparation of these nucleosides are provided and also a novel non-invasive method for the detection and measurement of tissue hypoxia in mammals.
Claims5
A method for the diagnostic imaging of hypoxic tissue in a mammal comprising the steps of
- (a) administering to the mammal a nucleoside having the formula ##STR4## wherein X is arabinofuranose monosaccharide, said monosaccharide having a hydrogen or hydroxide substituent replaced by a .gamma.-emitting halogen, wherein said nucleoside is taken up selectively by the hypoxic tissue;
- and
- (b) determining the .gamma.-emission from said halogen.
Dependencies are inferred from the claim text.