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US 5,399,775 AGranted
Process for preparing substituted cyclobutanes
AssigneeBristol-Myers Squibb Company
InventorsRichard J. Pariza, Steven M. Hannick, Thomas J. Sowin, Elizabeth M. Doherty
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Abstract
The present invention relates to a process for the preparation of substituted cyclobutanes and their use as intermediates for the preparation of anti-viral nucleoside analogs.
Claims1
A process for the preparation of the substantially pure enantiomer of the compound of the formula ##STR7## wherein R.sub.1 is hydrogen or t-butyldimethylsilyl comprising:
- (a) reacting the di-(-)-menthyl ester of fumaric acid with a compound of the formula ##STR8## in the presence of diisobutylaluminum chloride;
- (b) reducing the resulting diester to the diol;
- (c) optionally protecting the hydroxyl groups by reacting with t-butyldimethylsilyl chloride;
- and
- (d) hydrolyzing the dithioketal to the ketone.
2 more elements
Dependencies are inferred from the claim text.