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US 5,399,771 AGranted
Process of synthesizing binaphthyl derivatives
AssigneeMerck & Co., Inc.
InventorsDongwei Cai, Joseph F. Payack, Thomas R. Verhoeven
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Abstract
A process of synthesizing a compound of the formula 1: ##STR1## is disclosed, which comprises reacting a compound of the formula 2: ##STR2## with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.
Claims15
A process of synthesizing a compound of formula 1:
- ##STR12## comprising reacting a compound of the formula 2:
- ##STR13## wherein R is selected from the group consisting of triflate, mesylate and tosylate,
- with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.
A process of synthesizing a compound of formula 1:
- ##STR14## comprising reacting the R(+) isomer of a compound of the formula 2:
- ##STR15## wherein R is selected from the group consisting of triflate, mesylate and tosylate,
- with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce the R(+) isomer of a compound of formula 1.
A process of synthesizing a compound of formula 1:
- ##STR16## comprising reacting the S(-) isomer of a compound of the formula 2:
- ##STR17## wherein R is selected from the group consisting of triflate, mesylate and tosylate,
- with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce the S(-) isomer of a compound of formula 1.
Dependencies are inferred from the claim text.