DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same

Compounds of the formula ##STR73## in which P is hydroxy and T is the group -X.sup.2 -CR.sup.7a R.sup.7b -CHR.sup.8 -OH or T is hydrogen and P is the group O-CHR.sup.8 -CR.sup.7a R.sup.7b -X.sup.2 -OH and, wherein

• X.sup.1 is -S- or -SO-;
• X.sup.2 is -CO- or -CS-;
• R.sup.1 is hydrogen, halogen or lower alkyl optionally substituted by halogen or lower alkoxy;
• R.sup.2 and R.sup.3 are each independently selected from hydrogen, lower alkyl, halogen, amino, lower alkylamino, di-lower alkylamino, acylamino, lower alkoxy, lower alkoxymethoxy and a group OR.sup.4 ;
• R.sup.4 is hydrogen or an easily hydrolyzable group;
• R.sup.5 is hydrogen, optionally esterified carboxy or amidated (thio)carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted acyl or heterocyclyl;
• R.sup.6 and R.sup.7a are each independently hydrogen or lower alkyl;
• R.sup.7b is hydrogen, optionally substituted hydroxy, -NR-A or -N=B, in which R is hydrogen or lower alkyl, A is hydrogen, optionally substituted alkyl, lower cycloalkyl, iminoyl, (thio)acyl, esterified carboxy or amidated (thio)carboxy and B is lower alkylidene;
• or
• R.sup.7a and R.sup.7b together represent oxo, lower alkoxycarbonyl-methylidene or optionally substituted hydroxyimino;
• and
• R.sup.8 is hydrogen, optionally substituted alkyl, optionally esterified carboxy or amidated (thio)carboxy;
• provided that no more than two of R.sup.1 -R.sup.3 are nitrogen-containing groups;
• no more than two of R.sup.1 -R.sup.3 are oxygen containing groups and no more than two of R.sup.1 -R.sup.3 are either nitrogen containing or oxygen containing groups;
• or a reactive derivative thereof.