Cycloalkylthiazoles
AssigneeHoffmann-La Roche Inc.
InventorsGeorge W. Holland, John R. Vermeulen, William J. Zally
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Abstract
Compounds of the formula: ##STR1## wherein the substituents are as defined herein, and enantiomers, diastereomers, racemates and salts with pharmaceutically acceptable bases, antagonize LTD.sub.4 action and thus, are useful in treating bronchial asthma, pulmonary anaphylaxis, cystic fibrosis, chronic bronchitis, bronchiectasis, respiratory distress syndrome and pulmonary oedema.
Claims4
A compound of the formula ##STR19## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, carboxyl or alkoxycarbonyl;
- R.sup.3 is hydrogen, alkyl or cycloalkyl and
- X.sup.1 -- is halogen other than fluorine, provided that one of R.sup.1 or R.sup.3 is cycloalkyl.
A compound of the formula ##STR20## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, carboxyl or alkoxycarbonyl and
- R.sup.3 is hydrogen, alkyl or cycloalkyl, provided that one of R.sup.1 or R.sup.3 is cycloalkyl.
Dependencies are inferred from the claim text.