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US 5,399,696 AGranted
Isoquinolinyl compounds which are intermediates
AssigneeEli Lilly and Company
InventorsM. Brian Arnold, Nancy K. Augenstein, William H. W. Lunn, Paul L. Ornstein
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Abstract
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
Claims4
A compound of formula ##STR87## wherein:
- R.sup.9 is acyl, or alkoxycarbonyl;
- R.sup.10 is hydrogen, C.sub.1 -C.sub.6 alkyl or aryl;
- U is hydroxymethyl, formyl, bromomethyl, bromoethyl, or hydroxyethyl;
- V is hydrogen;
- or
- U and V together are methylene or methoxymethylene.
3 more elements
Dependencies are inferred from the claim text.