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US 5,399,681 AGranted
Method for preparing N.sup.6 -substituted NAD, NADP or FAD
AssigneesGesellschaft fur Biotechnologische Forschung mbH (GBF), Degussa AG
InventorAndreas F. Buckman
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Abstract
The invention relates to a method of preparing N.sup.6 -substituted NAD, NADP or FAD by Dimroth rearrangement, wherein the rearrangement is carried out without preceding reduction and subsequent reoxidation.
Claims9
A process of preparing N.sup.6 -substituted NAD or NADP, which consists essentially of;
- (a) alkylating the NAD or NADP in the N(1)-position with ethyleneimine to obtain the corresponding N(1)-(2-aminoethyl)-NAD or N(1)-(2-aminoethyl)-NADP;
- and
- (b) rearranging the alkylation product to obtain the corresponding N.sup.6 -(2-aminoethyl)-NAD or N.sup.6 -(2-aminoethyl)-NADP
- said rearrangement being carried out without first reducing the alkylation product.
1 more element
A process of preparing N.sup.6 -substituted NAD or NADP, which consists essentially of;
- (a) alkylating the NAD or NADP in the N(1)-position with ethyleneimine to obtain the corresponding N(1-(2-aminoethyl)-NAD or N(1)-(2-aminoethyl)-NADP;
- and
- (b) rearranging the alkylation product to obtain the corresponding N.sup.6 -(2-aminoethyl)-NAD or N.sup.6 -(2-aminoethyl)-NADP;
- said rearrangement being carried out without first reducing the alkylation product;
- and
- (c) covalently bonding the rearrangement product to a macromolecule.
3 more elements
A process for preparing N.sup.6 -substituted FAD, which consists essentially of;
- (a) alkylating FAD in the N(1)-position with ethyleneimine to obtain N(1)-(2-aminoethyl)-FAD;
- and
- (b) rearranging the alkylation product to obtain N.sup.6 -(2-aminoethyl)-FAD;
- said rearrangemet being carried out without first reducing the alkylation product.
1 more element
A process for preparing N.sup.6 -substituted FAD which consists essentially of;
- (a) alkylating FAD in the N(1)-position with ethyleneimine to obtain N(1)-(2-aminoethyl)-FAD;
- (b) rearranging the alkylation product to obtain N.sup.6 -(2-aminoethyl)-FAD;
- said rearrangement being carried out without first reducing the alkylation product;
- and
- (c) covalently bonding the alkylation product to a macromolecule.
2 more elements
Dependencies are inferred from the claim text.